Can Matching-Adjusted Indirect Comparison Methods Mitigate Placebo Response Differences Among Patient Populations in Adjunctive Trials of Brivaracetam and Levetiracetam?
نویسندگان
چکیده
منابع مشابه
Can Matching-Adjusted Indirect Comparison Methods Mitigate Placebo Response Differences Among Patient Populations in Adjunctive Trials of Brivaracetam and Levetiracetam?
BACKGROUND AND OBJECTIVE Patients with focal seizures recruited into adjunctive antiepileptic drug (AED) trials have become more refractory and severe over time; concurrently, placebo responses have increased. To attempt to account for heterogeneity among trials, propensity-score weighted patient-level data were used to indirectly compare placebo responses reported in brivaracetam and levetirac...
متن کاملLevetiracetam vs. brivaracetam for adults with refractory focal seizures: A meta-analysis and indirect comparison
PURPOSE The study aimed to compare the efficacy and tolerability of levetiracetam (LEV) and brivaracetam (BRV) in adults with refractory focal seizures. METHOD We systematically queried Medline, Embase, and the Cochrane Library. We looked for additional studies in the references of all identified publications and ClinicalTrials.gov. The cutoff day was November 6, 2015. Randomized, double-blin...
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Response to Zhang et al.: Levetiracetam vs. brivaracetam for adults with refractory focal seizures: A meta-analysis and indirect comparison
To the Editor, unmeasured confounding further undermines the validity of comparison between these trials. 6. Some of the studies in the meta-analysis included doses that were found to be non-therapeutic in the pivotal studies and have not been approved for clinical use (brivaracetam 5, 20 and 25 mg/day; levetiracetam 500 mg/day). As such, a brivaracetam dose of 5 mg/day should not be compared t...
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ژورنال
عنوان ژورنال: CNS Drugs
سال: 2017
ISSN: 1172-7047,1179-1934
DOI: 10.1007/s40263-017-0462-8